What is the mechanism of the analgesic action of aspirin?
Answer: Prostaglandins are local hormones that are manufactured and released when cell membranes are distorted and damages (injured). These prostaglandins act on the endings of the neurons that mediate pain in the injured areas, sensitizing the neurons to mechanical stimulation and to stimulation by two other local hormones, histamine and bradykinin (which are more slowly released from the damaged tissue). Aspirin blocks the synthesis of the prostaglandins by inhibiting two forms of the cyclooxygenase enzyme (COX-1 and COX-2), thus reducing pain.
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